Role for Recombinant -Glutamyltransferase from Treponema denticola in Glutathione Metabolism
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چکیده
Role for Recombinant -Glutamyltransferase from Treponema denticola in Glutathione Metabolism Lianrui Chu,* Xiaoping Xu, Zheng Dong,† David Cappelli, and Jefferey L. Ebersole Departments of Orthodontics, Periodontics, and Pathology and Community Dentistry, University of Texas Health Science Center, San Antonio, Texas 78229, and Center for Oral Health Research, University of Kentucky, Lexington, Kentucky 40536
منابع مشابه
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
The metabolism of glutathione by the periodontal pathogen Treponema denticola produces hydrogen sulfide, which may play a role in the host tissue destruction seen in periodontitis. H2S production in this organism has been proposed to occur via a three enzyme pathway, gamma-glutamyltransferase, cysteinylglycinase (CGase), and cystalysin. In this study, we describe the purification and characteri...
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Treponema denticola does not appear to produce siderophores, so it must acquire iron by other pathways. Indeed, T. denticola has been shown to have an iron-regulated 44-kDa outer membrane protein (HbpA) with hemin binding ability. To characterize the HbpA protein, its gene was cloned from genomic DNA libraries of T. denticola. Sequence analysis of the hbpA open reading frame indicated that it e...
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تاریخ انتشار 2002